Opioid Pain Control: Safe or Effective?

Is "safe effective glucose control" effective and safe?

Of note, the randomized controlled trials that showed a benefit from glucose control have tested only one and the same BGL target (4.4 to 6.1 mmol/l [80 to 110 mg/dl]) [2,3]. In addition, in these trials conventional insulin treatment was administered only when the BGL was >12 mmol/L (215 mg/dl), with insulin infusion gradually decreased and stopped when the BGL fell to <10 mmol/l (180 mg/dl). ...

Safe IV opioid titration in patients with severe acute pain.

PROVIDING EFFECTIVE PAIN control while minimizing opioid-induced adverse effects in patients with severe acute pain presents special challenges for clinicians who work in PACUs, outpatient surgery settings, emergency departments (EDs), and intensive care units (ICUs) because they must also deal with the additional central nervous system depression caused by the sedative and anesthetic agents th...

Opioid peptides in peripheral pain control.

Opioids have a long history of therapeutic use as a remedy for various pain states ranging from mild acute nociceptive pain to unbearable chronic advanced or end-stage disease pain. Analgesia produced by classical opioids is mediated extensively by binding to opioid receptors located in the brain or the spinal cord. Nevertheless, opioid receptors are also expressed outside the CNS in the periph...

Moving beyond tight glucose control to safe effective glucose control

The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach - Safe, Effective Glucose Control - that will essentially target an intermediate blood glucose level....

Breast Thermography Safe, effective, pain-free breast cancer screening